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pentobarbital will increase toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. CYP3A4 inducers may well enhance the metabolism of ifosfamide to its Energetic alkylating metabolites.pentobarbital will minimize the level or outcome of atogepant by influencing hepatic/intestinal enzyme CYP3A4 metaboli